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The Heart-Healthy Mushroom
Beyond its global culinary fame, Shiitake contains lentinan — a clinically validated immune activator — and eritadenine, a unique compound that supports healthy cholesterol metabolism.
Family
Marasmiaceae
Origin
East Asia — China, Japan, Korea
Primary Benefit
Cardiovascular & Immune Health
Lentinula edodes is the world's second most cultivated mushroom and one of the most medicinally significant. Lentinan, its primary beta-glucan, was approved as an injectable immunotherapy in Japan for gastric cancer treatment in 1985. Eritadenine, a unique adenine derivative found only in Shiitake, has been shown to support healthy cholesterol metabolism by inhibiting the enzyme that converts homocysteine to methionine, thereby reducing plasma cholesterol levels. Shiitake is also an exceptional source of ergothioneine and B vitamins, making it a nutritionally dense ingredient for cardiovascular and immune health products.
Immune System Activation
Lentinan activates macrophages, NK cells, and cytotoxic T-lymphocytes, providing potent immune surveillance support.
Supports Healthy Cholesterol
Eritadenine has been shown to reduce total plasma cholesterol and LDL levels in multiple animal and human studies.
Cardiovascular Health
Eritadenine, ergothioneine, and beta-glucans collectively support vascular health, healthy blood pressure, and reduced oxidative stress in the cardiovascular system.
Rich in B Vitamins & Minerals
Provides a natural source of B vitamins, copper, selenium, zinc, and manganese — essential micronutrients for energy and immune function.
Antiviral Properties
Lentinan and other polysaccharides demonstrate antiviral activity against influenza and other viruses in laboratory studies.
Get a free Shiitake extract sample for your formulation trials. B2B clients only.
Extraction Method
Hot water extraction to maximize lentinan and beta-glucan yield.
Standardization
Standardized to ≥25% polysaccharides with verified lentinan content.
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